Advanced Delivery of Poorly Water Soluble Drugs by Lipid Based Formulation as Smedds

نویسندگان

  • Amol S. Deshmukh
  • Vijay R. Mahajan
چکیده

INTRODUCTION Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Poor aqueous solubility of lipophilic drugs creates problems in formulation as well as in oral administration. Various approaches have been developed to resolve poor aqueous solubility of lipophilic drugs. As oral route for drug administration is most commonly used among all the routes of administration due to its convenience, noninvasiveness and cost effectiveness it become ABSTRACT Oral route has always been preferred route for formulators and has dominated over other routes of administrations. But major problem encountered in oral formulations, is low bioavailability, giving rise to further problems like, high inter and intra subject variability, lack of dose uniformity and finally leading to therapeutic failure. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Particularly for BCS class II substances, the bioavailability may be enhanced by increasing the solubility and dissolution rate of the drug in the gastro-intestinal fluids. The newer and novel technologies developed in recent year for troubleshooting such above problems. This review article gives a complete overview of SMEDDS as a capable approach to effectively capture the problem of poorly soluble molecules and give the novel approaches for evaluation of the SMEDDS.

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تاریخ انتشار 2015